Department of Health and Human Services: Oral Disease and Disorders Research
To obtain improved information on craniofacial-oral-dental health promotion, disease prevention, diagnostics, therapeutics, and fundamental scientific research that fuels the engine of patient-oriented and community-based clinical or applied research. The research portfolio is divided into several over-lapping programs which support basic, clinical and transitional research from molecular biology to patient-oriented and community-based clinical investigations. 1. Inherited Diseases and Disorders Program supports research on etiology, pathogenesis, epidemiology, prevention, diagnosis, and treatment of inherited craniofacial-oral-dental diseases and disorders (e.g., ectodermal dysphasia, cleft lip and palate, amelogenesis imperfecta, dentionogenesis imperfecta, osteogenesis imperfecta, and other inherited diseases that have craniofacial-oral-dental manifestations) as well as on normal craniofacial-oral-dental development. A developmentally related disorder such as occlusion defects and those acquired through trauma is included. 2. Infectious Diseases Program supports research on etiology, pathogenesis, epidemiology, prevention, diagnosis and treatment of oral infectious diseases (i.e., viral, bacterial, fungal and parasitic) such as dental caries, periodontitis, oral candidiasis, herpes, hepatitis, and HIV/AIDS. Included is research on immunity with special emphasis on mucosal and salivary immunity; and on the oral manifestations of systemic infectious diseases and the development of new diagnostics and therapeutics. 3. Neoplastic Diseases Program supports research on the etiology, pathogenesis and metastasis, epidemiology, prevention, diagnosis, and treatment of oral and pharyngeal neoplastic diseases. 4. Chronic Disabling Diseases Program supports the full range of research involving such diseases associated with the craniofacial-oral-dental complex. These include osteoporosis, osteoarthritis, and related bone disorders, temporomandibular joint diseases and disorders, neuropathies and neurodegenerative diseases including those involving oral sensory and motor functions, and autoimmune diseases such as Sjogren's syndrome. Also included is research aimed at elucidating the relationship between chronic diseases of the craniofacial-oral-dental complex (e.g., periodontitis) and other systemic diseases (e.g., diabetes). 5. Biomaterials, Bio- mimetics and Tissue Engineering Program supports research to enhance the development of natural and synthetic therapeutics and biomaterials used for the repair, regeneration, restoration, and reconstruction of craniofacial-oral-dental molecules, cells, tissues, and organs. 6. Behavior, Health Promotion and Environment Program supports research aimed at assessing the interactive roles of sociological, behavioral, economic, environmental, genetic, and biomedical factors in craniofacial-oral-dental diseases and disorders. Included are studies aimed at examining the impact of oral health care delivery systems, clinical decision-making, and education on health outcomes. The Institute also supports Comprehensive Oral Research Centers of Discovery, each of which is organized around a unifying scientific theme pertinent to diseases and disorders of the craniofacial-oral-dental complex, integrates basic, clinical, applied and behavioral research, accelerated science-technology transfer, provides a vehicle for cross-disciplinary and collaborative research, and provides health professionals and the public with the latest information about craniofacial-oral-dental health. The Research Training and Career Program insures the future of craniofacial-oral-dental research by developing an outstanding and diverse scientific work force through programs designed for high school, undergraduate, graduate, and post-doctoral stages of education and for continued career development of scientists and retraining of mid-career scientists. The Diversity in Research portfolio enhances research on minority craniofacial-oral- dental health issues, expands the diversity of the scientific work force, and increases the research capacity of minority institutions and of those serving primarily minority populations. The Clinical Trials and Clinical Core Centers portfolio recognizes the increasing need to establish a strong foundation for the support of meritorious clinical research. The Technology Transfer portfolio responds to the increasing partnering of the Institute's Division of Extramural Research with industry in craniofacial-oral-dental research. It expands on the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs and works closely with the industrial R&D community to identify new opportunities for fostering collaborative efforts. The SBIR program seeks to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The STTR program seeks to stimulate and foster scientific and technological innovation and foster technology transfer through cooperative research and development carried out between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.121
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Department of Health and Human Services: Human Genome Research
To obtain genetic maps, physical maps, and determine the deoxyribonucleic acid (DNA) sequences of the genomes of humans and model organisms to be used as resources in biomedical research, medicine, and biotechnology. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.172
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Department of Health and Human Services: Research Related to Deafness and Communication Disorders
To obtain genetic maps, physical maps, and determine the deoxyribonucleic acid (DNA) sequences of the genomes of humans and model organisms to be used as resources in biomedical research, medicine, and biotechnology. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.173
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Department of Health and Human Services: Research and Training in Complementary and Alternative Medicine
To support hypothesis-, design-, technology-, or devise-driven research relation to the discovery, design, development, validation, and application of technologies related to biomedical imaging and bioengineering. The program includes biomaterials (biomimetics, bioprocessing, organogenesis, rehabilitation, tissue engineering, implant science, material science, interface science, physics and stress engineering, technology assessment of materials/devices), biosensors/biotransducers (technology development, technology assessment, development of algorithms, telemetry), nanotechnology (nanoscience, biomimetics, drug delivery systems, drug bioavailability, microarray/combinatorial technology, genetic engineering, computer science, technology assessment), bioinformatics (computer science, information science, mathematics, biomechanics, computational modeling and simulation, remote diagnosis and therapy), imaging device development, biomedical imaging technology development, image exploitation, contrast agents, informatics and computer sciences related to imaging, molecular and cellular imaging, bioelectrics/biomagnetics, organ and whole body imaging, screening for diseases and disorders, and imaging technology assessment and surgery (technique development and technology development).
Deadline is September 7, 2008. CFDA # 93.213
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Department of Health and Human Services: Alcohol National Research Service Awards for Research Training
To assure the maintenance of an adequate supply of well-trained alcohol researchers through the award of both individual fellowships and grants to training institutions for support of training at both the predoctoral and postdoctoral levels and for Senior Fellowships and M.D./Ph.D. Fellowships. Special predoctoral fellowships are also available for students with disabilities and for minority students. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) supports awards for training in clinical research, treatment assessment research, problems of health promotion and alcoholism prevention, and basic biological and behavioral processes applicable to alcohol research.
Deadline is September 7, 2008. CFDA # 93.272
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Department of Health and Human Services: Drug Abuse Research Programs
To support epidemiologic, basic, clinical, applied and health services research to develop new knowledge and approaches related to the prevention, treatment, etiology, and consequences of addiction and drug abuse, including HIV/AIDS. This program focuses to support research training and research scientist development. This programs is to support dissemination of research findings. Small Business Innovation Research (SBIR) program: to expand and improve the SBIR program. The legislation is intended to expand and improve the SBIR programs to emphasize and increase private sector commercialization of technology developed through Federal SBIR research and development; increase small business participation in Federal research and development; and foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. The legislation intends that the Small Business Technology Transfer (STTR) program stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.279
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Department of Health and Human Services: Mental Health National Research Service Awards for Research Training
To ensure a continuing and adequate supply of well-trained scientists who are able to conduct research on mental health problems. The program provides training grants to institutions and fellowships to individuals at both the predoctoral and postdoctoral levels. There are awards to medical students proposing to acquire doctoral research degrees in addition to their medical degrees. In addition, there are special programs designed to address the under representation of women and ethnic minority groups in biomedical and behavioral science relevant to mental health. Awards are made for training in the areas of basic and clinical neuroscience, genetics, developmental, behavioral, clinical, epidemiological, prevention, treatment and services research relevant to mental illness, behavioral disorders, and HIV/AIDS; and programs designed to increase the number of individuals in mental health research who are from underrepresented racial and ethnic groups, individuals with disabilities, or individuals disadvantaged because of educational or other circumstances that have inhibited their ability to pursue such a career.
Deadline is September 7, 2008. CFDA # 93.282
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Department of Health and Human Services: Discovery and Applied Research for Technological Innovations to Improve Human Health
To support hypothesis-, design-, technology-, or devise-driven research relation to the discovery, design, development, validation, and application of technologies related to biomedical imaging and bioengineering. The program includes biomaterials (biomimetics, bioprocessing, organogenesis, rehabilitation, tissue engineering, implant science, material science, interface science, physics and stress engineering, technology assessment of materials/devices), biosensors/biotransducers (technology development, technology assessment, development of algorithms, telemetry), nanotechnology (nanoscience, biomimetics, drug delivery systems, drug bioavailability, microarray/combinatorial technology, genetic engineering, computer science, technology assessment), bioinformatics (computer science, information science, mathematics, biomechanics, computational modeling and simulation, remote diagnosis and therapy), imaging device development, biomedical imaging technology development, image exploitation, contrast agents, informatics and computer sciences related to imaging, molecular and cellular imaging, bioelectrics/biomagnetics, organ and whole body imaging, screening for diseases and disorders, and imaging technology assessment and surgery (technique development and technology development).
Deadline is September 7, 2008. CFDA # 93.361
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Department Health and Human Services: Nursing Research
The National Institute of Nursing Research supports clinical and basic research to establish a scientific basis for the care of individuals across the life span from management of patients during illness and recovery to the reduction of risks for disease and disability and the promotion of healthy lifestyles. According to its broad mandate, the Institute seeks to understand and ease the symptoms of acute and chronic illness, to prevent or delay the onset of disease or disability or slow its progression, to find effective approaches to achieving and sustaining good health, and to improve the clinical settings in which care is provided. The NINR's research extends to problems encountered by patients, families, and caregivers. It also emphasizes the special needs of at-risk and underserved populations. These efforts are crucial in translating scientific advances into cost- effective health care that does not compromise quality. NINR accomplishes its mission by supporting grants to universities and other research organizations as well as by conducting research intramural at laboratories in Bethesda, Maryland. The research fosters multi- disciplinary collaborations to ensure a comprehensive approach to research on illness and disabling conditions. This approach is especially relevant in research aimed at long-term care for the elderly, the special needs of women across the life span, bioethical issues related to genetic testing and counseling, biobehavioral aspects of managing the prevention and treatment of infectious diseases, and environmental influences on risk factors related to chronic illnesses. In addition, the Institute supports comprehensive research training programs to prepare individuals with requisite interdisciplinary skills to conduct nursing research. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged mall business concerns and women-owned small business concerns in technological innovation Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Centers Program: To promote interdisciplinary research, offer an environment for research training and career development, and concentrate research through Core Centers for Nursing Research.
Deadline is September 7, 2008. CFDA # 93.361
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Department of Health and Human Services: Cancer Research Manpower
The Research Manpower program provides support for research training in all scientific fields related to cancer. The Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Fellows, are made directly to individuals for research training in biomedical sciences areas. In addition, the National Institutes of Health (NIH) will award the Ruth L. Kirschstein NRSA Institutional Research Training grants to institutions, to enable them to make NRSA awards to individuals selected by them. Each individual who receives a postdoctoral NRSA is obligated, upon termination of the award, to comply with certain service and payback provisions. Cancer Education Grants are designed to promote education programs carried out by organizations engaged in health-related education, research, or training, located in the United States, its possessions, or territories. Various Career awards are designed to sponsor the development of independent scientists. Individual short-term support for students is available under the Cancer Education Program.
Deadline is September 7, 2008. CFDA # 93.398
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Department of Health and Human Services: Lung Disease Research
To use available knowledge and technology to solve specific disease problems of the lungs; to promote further studies on the structure and function of the lung; and to achieve improvement in the prevention and treatment of lung diseases. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation
Deadline is September 7, 2008. CFDA # 93.838
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Department of Health and Human Services: Blood Diseases and Resources Research
To foster research and research training on the pathophysiology, diagnosis, treatment, and prevention of non-malignant blood diseases, including anemias, sickle cell disease, thalassemia; leukocyte biology, pre-malignant processes such as myelodysplasia and myeloproliferative disorders; hemophilia and other abnormalities of hemostasis and thrombosis; and immune dysfunction. Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. Programs also support the development of novel cell-based therapies to bring the expertise of transfusion medicine and stem cell technology to the repair and regeneration of human tissues and organs. Small Business Innovation Research (SBIR) program: To stimulate technological innovation; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.839
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Department of Health and Human Services: Arthritis, Musculoskeletal and Skin Diseases Research
To support research relevant to arthritis, musculoskeletal and skin diseases, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports research training and basic and clinical investigations including epidemiology and clinical trials in each of the following program areas: The Arthritis Program supports research related to all forms of arthritis including rheumatoid arthritis, systemic connective tissue diseases, osteoarthritis, and metabolic and infectious types of arthritis. The Muscle Biology Program supports research on basic aspects of muscle physiology and disease and exercise physiology. The Musculoskeletal Diseases Program supports research relating to orthopaedic problems, osteoarthritis, bone diseases and bone metabolism, most specifically Osteoporosis and Paget's Disease, heritable disorders of connective tissue, and programs relating to the affects of mechanical forces on musculoskeletal disease, as well as exercise and sports medicine. The Skin Diseases Program supports all forms of research on skin diseases, in particular diseases of keratin, pigmentation, basement membranes, and heritable disorders. The Centers Program supports large programs in arthritis and musculoskeletal and skin diseases. Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA #93.846
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Department of Health and Human Services: Kidney Disease, Urology and Hematology Research.
To encourage basic and clinical research and research training to improve understanding of the mechanisms underlying diseases in the nephrologic, urologic, and hematologic systems; to promote the development of improved diagnostic tools and therapies for these diseases. Supported nephrologic research includes studies of the development, physiology, and cell biology of the kidney, pathophysiology of the kidney, genetics of kidney disorders, immune mechanisms of kidney disease, kidney disease as a complication of diabetes, effects of drugs, nephrotoxins and environmental toxins on the kidney, and mechanisms of kidney injury repair. Of special interest is improved diagnosis, prevention and treatment of chronic kidney disease and endstage renal disease, and improved approaches to maintenance dialysis therapies. Supported urological research includes basic studies of lower urinary tract cell biology, development, physiology, and pathophysiology, and clinical studies of bladder dysfunction, incontinence, pyelonephritis, interstitial cystitis, benign prostatic hyperplasia, and vesicoureteral reflux. The development of novel diagnostic tools and improved therapies, including tissue engineering strategies, for urologic disorders is a priority. Hematologic research emphasizes basic biomedical research on hematopoietic cell differentiation, metabolism of iron overload and deficiency, and the structure, biosynthesis and genetic regulation of hemoglobin as well as research on the etiology, pathogenesis, and therapeutic modalities for the anemias of chronic renal failure and other chronic diseases,. 2) To foster, via National Research Service Award (NRSA) and other training mechanisms, the training and career development of scientists interested in pursuing research in the above areas. 3) Small Business Innovation Research (SBIR) program: to increase small business participation in research in the areas described above, to increase private sector commercialization of innovations derived from Federal research and development, and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. 4) Small Business Technology Transfer (STTR) program: to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions, to foster technology transfer between small business concerns and research institutions, to increase private sector commercialization of innovations derived from Federal research and development, and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Deadline is September 7, 2008. CFDA # 93.853
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Department of Health and Human Services: Extramural Research Programs in the Neurosciences and Neurological Disorders
To support extramural research within the National Institute of Neurological Disorders and Stroke (NINDS) including: neurological science basic research that explores the fundamental structure and function of the brain and the nervous system; research to understand the causes and origins of pathological conditions of the nervous system with the goal of prevention of these disorders; research on the natural course of neurological disorders; research on mechanisms associated with stroke and other cerebrovascular disorders, effects of trauma to the nervous system, neuroplasticity and regeneration, and tumors of neural and sensory tissues; improved methods of disease prevention; new methods of diagnosis and treatment; clinical trials; drug development; development of neural prostheses for stroke and paraplegia; epidemiological research; and research training in the clinical neurosciences. Programmatic areas within this Institute support research on such topics as stroke; traumatic injury to the brain, spinal cord and peripheral nervous system; neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease; brain tumors; development of artificial prosthetic devices to restore function to the damaged nervous system; convulsive disorders, including epilepsy; infectious disorders of the brain and nervous system, including AIDS; immune disorders of the brain and nervous system, including multiple sclerosis; disorders related to sleep; and pain. Programmatic areas also include neurodevelopment, repair and plasticity, channels synapses and circuits, neurogenetics, neurodegeneration, neural environment, and systems and cognitive neuroscience. Extramural research is also supported by the Office of Minority Health and Research. (2) To expand and improve the Small Business Innovation Research (SBIR) program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. (3) To utilize the Small Business Technology Transfer (STTR) program; to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The NINDS also participates in the Academic Research Enhancement Award (AREA) Program, which is intended to provide research support to institutions currently having little National Institutes of Health (NIH) support.
Deadline is September 7, 2008. CFDA # 93.856
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Department of Health and Human Services: Biomedical Research and Training
The National Institute of General Medical Sciences supports basic biomedical research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. The Institute's programs encompass the areas of cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, bioinformatics, computational biology, and minority biomedical research and training.
Deadline is September 7, 2008. CFDA # 93.859
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